GlycoProfileAssigner: automated structural assignment with error estimation for glycan LC data

MOTIVATION Sequencing glycan structures is a difficult problem that requires the use of multiple experimental approaches. One powerful approach to glycan sequencing is the combination of liquid chromatography with sequential exoglycosidase digestions; however, interpreting this can be difficult and time-consuming. To aid this process, we introduce GlycoProfileAssigner, software for automated structural assignment of glycan profile data from liquid chromatography experiments. RESULTS GlycoProfileAssigner has been tested on human IgG data, and can retrieve the correct structure in 14 out of 16 peaks tested. AVAILABILITY AND IMPLEMENTATION The programme and its source code is available at https://bitbucket.org/fergaljd/glycoprofileassigner CONTACT : [email protected] SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.